17a-Hydroxyprogesterone Caproate CAS 630-56-8
17α-Hydroxyprogesterone caproate is a synthetic steroid hormone that is similar to medroxyprogesterone acetate and megestrol acetate. It is an ester derivative of 17α-hydroxyprogesterone formed from caproic acid (hexanoic acid).
Progesterone Hormones Raw Steroid Powders 17a-Hydroxyprogesterone Caproate CAS 630-56-8
Product Name: 17a-Hydroxyprogesterone caproate
Synonyms: PREGN-4-ENE-3,20-DIONE HEXANOATE;17-((1-oxohexyl)oxy)-pregn-4-ene-20-dione;17-((1-Oxohexyl)oxy)pregn-4-ene-3,20-dione;17a-hydroxyprogesteronehexanoate;17-alpha-Hexanoyloxypregn-4-ene-3,20-dione;17alpha-Hydroxyprogesterone n-caproate;17-alpha-hydroxyprogesteronen-caproate;17-Hydroxypregn-4-ene-3,20-dione caproate
17a-Hydroxyprogesterone Caproate Description:
(1). 17α-Hydroxyprogesterone caproate is a synthetic steroid hormone that is similar to medroxyprogesterone acetate and megestrol acetate. It is an ester derivative of 17α-hydroxyprogesterone formed from caproic acid (hexanoic acid).
(2). 17α-Hydroxyprogesterone caproate was previously marketed under the trade name Delalutin by Squibb, which was approved by the U.S. Food and Drug Administration (FDA) in 1956 and withdrawn from marketing in 1999.
(3). The US FDA approved Makena from KV Pharmaceutical (previously named as Gestiva) on February 4, 2011 for prevention of preterm delivery in women with a history of preterm delivery, sparking a pricing controversy.
17a-Hydroxyprogesterone Caproate Applications:
(1). This medication is used in women who are pregnant with a single baby, and who have delivered a baby too early (preterm) in the past. It is used to help lower the risk of having a preterm baby again. Hydroxyprogesterone is a man-made form of a female hormone (progestin). It is not known how it works to prevent preterm labor.
(2). This medication is not intended to prevent preterm birth in women pregnant with more than one baby (such as twins, triplets). It is also not intended to stop active preterm labor.
17a-Hydroxyprogesterone Caproate Specifications:
|Description||White or almost white crystalline powder, odorless||Conforms|
|Solubility||insoluble in water, solube in ether, slightly soluble in benzene||Conforms|
|Specific Optical Rotation||+58°—+64° (1% chloroform Solution)||60.3°|
|Melting Point||about 120 -124 ℃||123℃|
|Free N-Caproic Acid||≤0.58%||0.20%|
|Residual Solvents||Methanol ≤ 3000PPM||1280PPM|
|Dichloromethane ≤ 600PPM||80PPM|
|Conclusion||Conforms to USP31|
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