Cyproterone Acetate CAS 427-51-0
Professional Anti Androgen Cyproterone Acetate For Man Antiandrogen 427-51-0
1. Cyproterone Acetate Description:
Product name: Cyproterone Acetate
English Synonyms: 1,2-alpha-methylene-6-chloro-delta-(sup4,6)-pregnadiene-17-alpha-ol-3,20-dio;
CAS NO.: 427-51-0
Appearance: White crystalline powder
Usage: Anti-androgen for the treatment of men with BPH, and can be used as male contraceptive
Quality Standard: EP5
Delivery: Express courier.
2. Cyproterone Acetate Usage:
Cyproterone acetate (INN, USAN, BAN, JAN), sometimes abbreviated as CPA, and sold under brand names such as Androcur and Cyprostat, is a synthetic steroidal antiandrogen drug with additional progestogen and antigonadotropic properties. Its primary action is to suppress the activity of the androgen hormones such as testosterone and its more potent metabolite dihydrotestosterone (DHT) in the body, effects which it mediates via competitive antagonism of the androgen receptor and inhibition of enzymes in the androgen biosynthesis pathway. The main therapeutic indications of cyproterone acetate are prostate cancer, benign prostatic hyperplasia, priapism, hypersexuality (e.g., as a form of chemical castration), and other conditions in which androgen action maintains the disease process. In addition, it can also be used to treat acne and hirsutism in females, and is a common component in hormone therapy for transsexual women. In addition to its antiandrogen properties, cyproterone acetate has weak progestogen activity (i.e., it acts like progesterone). Accordingly, it can be used to treat hot flashes, and is also a component of some combined oral contraceptive pills such as Dianette in the United Kingdom and Diane-35 in other countries such as Canada. It is called Dixi-35 in Chile. No form of cyproterone acetate is available in the United States. Until the development of leuprorelin, cyproterone acetate was one of the few drugs used to treat precocious puberty. It was also used in animal experimentation to investigate the actions of androgens in fetal sexual differentiation.
3. Cyproterone Acetate Specification:
|Product Name||Cyproterone Acetate||Quantity||130kg|
|Produce Date||2014.04.01||Report Date||2014.04.02|
|Description||White or almost white Crystalline Powder|
|Results of Analysis Tests|
|Test||Analysis Standard||Results of Analysis|
|Melting Point||About 210||210.5|
|Loss On Drying||≤0.5%||0.24%|
|Related Substance by HPLC||≤0.5% Not more than 0.5%||0.3%|
|Sulphate ash||≤0.1% Not more than 0.1%||0.035%|
|Conclusion||The specification conform with EP6|
The direct antiandrogenic effect of cyproterone is to block the binding of dihydrotestosterone to the specific receptors in the prostatic carcinoma cell. In addition, cyproterone exerts a negative feed-back on the hypothalamo-pituitary axis, by inhibiting the secretion of LH resulting in diminished production of testicular testosterone.
Cyproterone belongs to a group of medications known as steroidal antiandrogens. It is used to treat advanced prostate cancer.Antiandrogens such as cyproterone block the effect of the hormone called testosterone. This causes a reduction in the production of testosterone in the testicles, which prostate cancer cells require for growth.
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