Dibucaine Hydrochloride CAS 61-12-1

01 Overview

Dibucaine hydrochloride is a local anesthetic drugs of the amide type now generally used for surface anesthesia . It is one of the most potent and toxic of the long-acting local anesthetics and its parenteral use is restricted . The drug blocks both the initiation and conduction of nerve impulses by decreasing the neuronal membrane's permeability to sodium ions.

02 Details

Surface / Spinal Local Anesthetic Powder Dibucaine Hydrochloride CAS 61-12-1

 

Basic information
English name: Dibucaine hydrochloride
English Name: Cinchocaine hydrochloride; 2-butoxy-n- (2- (diethylamino) ethyl) -4-quinolinecarboxamidmonohydrochlorid; 2-butoxy-n- (2- (diethylamino) ethyl) -cinchoninamidmonohydrochloride; 2-butoxy-n- (2 -diethylaminoethyl) cinchoninicacidamidehydrochloride; 2-n-butoxy-n- (2-diethylaminoethyl) cinchoninamidehydrochloride; 4-Quinolinecarboxamide, 2-butoxy-N- [2- (diethylamino) ethyl] -, monohydrochloride; Benzolin (localanesthetic); Butoxycinchoninicaciddiethylethylenediamidehydrochloride; C3225; 2 – {[(2-butoxyquinolin-4-yl) carbonyl] amino} -N, N-diethylethanaminium chloride; 2-butoxy-N- [2- (diethylamino) ethyl] quinoline-4-carboxamide dihydrochloride; Dibucaine HCl; Cinchocaine HCl
CAS: 61-12-1
EINECS number: 200-498-1
Molecular formula: C20H31Cl2N3O2
Molecular weight: 416.385
MP: 99-101 º C
Boiling point: 544.7 ° C at 760 mmHg
Flash Point: 283.2 ° C
Vapor Pressure: 3.37E-12mmHg at 25 ° C
Properties:
MP 99-101 ° C
Product use: Used as a local anesthetic

 

Dibucaine hydrochloride description:

 

  • Dibucaine hydrochloride is a local anesthetic drugs of the amide type now generally used for surface anesthesia . It is one of the most potent and toxic of the long-acting local anesthetics and its parenteral use is restricted . The drug blocks both the initiation and conduction of nerve impulses by decreasing the neuronal membrane’s permeability to sodium ions. This reversibly stabilizes the membrane and inhibits depolarizatioN resulting in the failure of a propagated action potential and subsequent conduction blockade .
  • In combination sodium dibucaine hydrochloride is administered to dogs to induce rapid , humane , painless euthanasia . The euthanasia solution is toxic to wildlife. Euthanized animals must be properly disposed of by deep burial , incineration or other method in compliance with state and local laws .

Applications

Dibucaine Hydrochloride – A local anesthetic of the amide type now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local anesthetics and its parenteral use is restricted to spinal anesthesia. (From Martindale, The Extra Pharmacopoeia, 30th ED, p1006) Indication: For production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks. Dibucaine Hydrochloride is an amide-type local anesthetic, similar to lidocaine.

 

Product Name dibucaine hydrochloride
Synonyms cinchocaine hydrochloride; 2-butoxy-n-(2-(diethylamino)ethyl)-4-
quinolinecarboxamidmonohydrochlorid; 2-butoxy-n-(2-(diethylamino)ethyl)-
cinchoninamidmonohydrochloride; 2-butoxy-n-(2-diethylaminoethyl)
cinchoninicacidamidehydrochloride; 2-n-butoxy-n-(2-diethylaminoethyl)
cinchoninamidehydrochloride; 4-Quinolinecarboxamide,2-butoxy-N-[2-
(diethylamino)ethyl]-,monohydrochloride; benzolin(localanesthetic);
butoxycinchoninicaciddiethylethylenediamidehydrochloride; c3225;
2-{[(2-butoxyquinolin-4-yl)carbonyl]amino}-N,N-diethylethanaminium chloride;
2-butoxy-N-[2-(diethylamino)ethyl]quinoline-4-carboxamide dihydrochloride;
Dibucaine HCL; Cinchocaine HCl
Molecular Formula C20H31Cl2N3O2
Molecular Weight 416.385
InChI InChI=1/C20H29N3O2.2ClH/c1-4-7-14-25-19-15-17(16-10-8-9-11-18(16)22-19)
20(24)21-12-13-23(5-2)6-3;;/h8-11,15H,4-7,12-14H2,1-3H3,(H,21,24);2*1H
CAS Registry Number 61-12-1
EINECS 200-498-1
Molecular Structure  
Melting point 99-101C
Boiling point 544.7°C at 760 mmHg
Flash point 283.2°C
Vapour Pressure 3.37E-12mmHg at 25°C

 

 

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