Estradiol Cypionate / Depofemin CAS 313-06-4
01 Overview
Estradiol cypionate (INN, USAN; DepoEstradiol, Depofemin, Estradep, many others), or estradiol cipionate, is a synthetic ester, specifically the 3cyclopentylpropanoyl ester, of the natural estrogen, estradiol.
estradiol-cypionate
Estradiol Cypionate02 Details
CAS 313-06-4 Sex Hormone Anti Estrogen Steroids Estradiol Cypionate / Depofemin For Reproductive System Development
1 . Product Profile
Product Name: Depofemin / Estradiol Cypionate
CAS: 313-06-4
EINECS Number: 206-237-8
Formula: C26H36O3
MW: 396.5622
Density: 1.15g / cm3
Boiling point: 532.8 ° C at 760 mmHg
Flash Point: 207.7 ° C
Vapor Pressure: 5.73E-12mmHg at 25 ° C
Assay:99%
Specification: USP/BP
Appearance: white crystalline powder
2.Detailed description
(1)Depofemin is a sex hormone that is present in both males and females, and is the most important form of estrogen in humans. In women, it plays a key role in the development and functioning of the reproductive system, as well as in the growth of certain bones. It also governs the distribution of body fat in women and is the main hormone responsible for the fact that women are shorter than men, on average. Both the ovaries and the adrenal glands produce it.
(2)The menstrual cycle in women involves predictable variations in the levels of several hormones, with estradiol being one of them. It is involved in the ovulation process and prepares the inner lining of the uterus for implantation, should the egg be fertilized. Certain tests done on baboons and other primates have indicated that his hormone also plays a continual role in maintaining a pregnancy, helping it to last for the full gestation period.
(3)As a sex hormone, it also triggers many of the developments of the reproductive system that begin in puberty. It is present throughout the reproductive years, and declines during and after menopause. This decline is precisely what causes many of the symptoms of menopause, such as hot flashes and night sweats, vaginal dryness, and the loss of bone mass that may lead to osteoporosis.
Estradiol cypionate COA :
| Test Items | Specification | Test Results |
| Appearance | White crystalline powder | White crystalline powder |
| Identification | IR , UV positive | Conform |
| Loss on drying | NMT 0.5% | 0.17% |
| Residue on ignition | NMT 0.2% | 0.04% |
| Iron | NMT 0.005% | 0.0018% |
| Heavy metals | NMT 0.001% | 0.0002% |
| Related substances | Total impurities: NMT 1.0% Any individual impurity: NMT 0.5% |
0.39% Complies |
| E-isomer | NMT 0.3% | 0.19% |
| Organic volatile impurities | Up to standard | Complies |
Other ref.:
Estradiol cypionate (INN, USAN; DepoEstradiol, Depofemin, Estradep, many others), or estradiol cipionate, is a synthetic ester, specifically the 3cyclopentylpropanoyl ester, of the natural estrogen, estradiol. It was first introduced in 1952 by Upjohn in the United States,and has been in widespread use since. Estradiol cypionate is absorbed more slowly than estradiol itself, and for that reason, it can be administered less often.
Estradiol cypionate was found to have the longest duration of action with a duration of ~11 days, while estradiol benzoate and estradiol valerate were found to last for 4–5 days and 7–8 days, respectively.
In the female, estradiol acts as a growth hormone for tissue of the reproductive organs, supporting the lining of the vagina, the cervical glands, the endometrium, and the lining of the fallopian tubes. It enhances growth of the myometrium. Estradiol appears necessary to maintain oocytes in the ovary.
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