Vardenafil / Levitra CAS 224785-91-5
01 Overview
Vardenafil (Levitra) is in a class of medications called phosphodiesterase (PDE) inhibitors. It works by increasing blood flow to the penis during sexual stimulation.
vardenafil-1
Vardenafil02 Details
Male Enhancement Steroids Vardenafil / Levitra For Sex Enhancement 224785-91-5
Vardenafil
Product Name: Vardenafil hydrochloride
Synonyms: 1-[[3-(1,4-dihydro-5-methyl-4-oxo-7-propylimidazo[5,1-f][1,2,4]triazin-2-yl)-4-ethoxyphenyl]sulfonyl]-4-ethyl-piperazine dihydrochloride;VARDENAFIL;VARDENAFIL, HYDROCHLORIDE SALT;vardenafil hydrochloride;VARDENAFIL HCL;Vardenafil Hydrochloride Trihydrate 224785-90-4 /;Levitra,Valdenafil.HCl;1-[[3-(1,4-Dihydro-5-methyl-4-oxo-7-propylimidazo[5,1-f][1,2,4]triazin-2-yl)-4-ethoxyphenyl]sulfonyl]-4-ethyl-piperazine
CAS: 224785-91-5
MF: C23H33ClN6O4S
MW: 525.06
Chemical Properties White to Off-White Cyrstalline Solid
Usage A selective phsphodiesterase type 5 (PDE5) inhibitor
Usage A phsphodiesterase 5 inhibitor.
Vardenafil Description:
Vardenafil (INN) is a PDE5 inhibitor used for treating erectile dysfunction. Vardenafil’s indications and contra-indications are the same as with other PDE5 inhibitors; it is closely related in function to sildenafil citrate (Viagra) and tadalafil (Cialis). The difference between the vardenafil molecule and sildenafil citrate is a nitrogen atom’s position and the change of sildenafil’s piperazine ring methyl group to an ethyl group. Tadalafil is structurally different from both sildenafil and vardenafil. Vardenafil’s relatively short effective time is comparable to but somewhat longer than sildenafil’s.
Vardenafil Applications:
Beyond its indications for erectile dysfunction, vardenafil may be effective in the treatment of premature ejaculation, where it may significantly increase the time from vaginal penetration to ejaculation.
Vardenafil, as with all PDE5 inhibitors, should not be used by men taking nitrate medications, because combining them with vardenafil might provoke potentially life-threatening hypotension (low blood pressure).
Further, Vardenafil causing lengthening of the QT interval. Therefore it should not be taken by men taking other medications that affect the QT interval (such as amiodarone).
Vardenafil COA:
| Test Items | Specification | Test Results |
| Description | White or almost white crystalline powder | White crystalline powder |
| Melting Point | 191.0～193.0℃ | 192℃ |
| Loss of drying | ≤1.0% | 0.5% |
| Heavy Metal | ≤20ppm | 15ppm |
| TLC | Only one spot | Only one spot |
| Assay | ≥99.5% | 99.91% |
| Conclusion | It complies with the USP 32. | |
Comparison of All Currently Available PDE5 Inhibitors in the United States
| Avanafil | Sildenafil | Vardenafil | Tadalafil | |
|---|---|---|---|---|
| Onset of action | 15-30 minutes | 30-60 minutes | 30-60 minutes | 60-120 minutes |
| Plasma half-life | 3 hours | 4 hours | 4 hours | 17.5 hours |
| Duration of action | Up to 6 hours | Up to 12 hours | Up to 10 hours | Up to 36 hours |
| Effect of food intake | Not affected | High-fat meals decrease efficacy | High-fat meals decrease efficacy | Not affected |
| Unique side effects | Vision abnormalities (PDE6) | Vision abnormalities (PDE6) | Back pain, myalgias |
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