Aarticaine Hydrochloride CAS 23964-57-0

01 Overview

Articaine is used for pain control. Like other local anesthetic drugs, articaine causes a transient and completely reversible state of anesthesia (loss of sensation) during (dental) procedures.

02 Details

Dental Local Anesthetic Drugs Articaine HCL / Articaine Hydrochloride CAS 23964-57-0

 

1 . Basic View

Product Name Articaine Hydrochloride
Synonyms methyl 4-methyl-3-[[(1-oxo-2-(propylamino)propyl]amino]-2-thenoate monohydrochloride; Carticaine HCl; Ultracaine; CARTICAINE HYDROCHLORIDE; Ultracain;Articaine hydrochloride; Methyl 4-methyl-3-(2-propylaminopropanoylamino)thiophene-2-carboxylate hydrochloride; 4-methyl-3-[2-(propylamino)propanoylamino]thiophene-2-carboxylic acid methyl ester hydrochloride
CAS 23964-57-0
MF C13H20N2O3S.ClH
MW 320.839
EINECS 245-957-7
Categories Local anesthetic; Pharmaceutical intermediate

 

 

3 . Description

Articaine hydrochloride, its CAS NO. is 23964-57-0, the synonyms are 2-Thiophenecarboxylic acid,4-methyl-3-((1-oxo-2-(propylamino)propyl)amino)-, methyl ester, monohydrochloride ; 4-Methyl-3-(2-(propylamino)propionamido)-2-thiophenecarboxylic acid methyl ester HCl ; Articaine HCl ; Methyl4-methyl-3-(2-(propylamino)propionamido)-2-thiophenecarboxylate, monohydrochloride ; Septanest ; Septocaine. Articaine is a dental local anesthetic. It is the most widely used local anesthetic in a number of European countries and is available in many countries around the world.
 

4 . Application

  • Structure and Metabolism

The amide structure of articaine is similar to that of other local anesthetics, but its molecular structure differs through the presence of a thiophene ring instead of a benzene ring. Articaine is exceptional because it contains an additional ester group that is metabolized by esterases in blood and tissue. The elimination of articaine is exponential with a half-life of 20 minutes. Since articaine is hydrolized very quickly in the blood, the risk of systemic intoxication seems to be lower than with other anesthetics, especially if repeated injection is performed.

Articaine is a local anaesthetic that has been approved overseas for several years. Like other amide anaesthetics, articaine blocks nerve conduction when it is infiltrated around a nerve. This action is prolonged by combining the drug with a vasoconstrictor such as adrenaline.
The combination of articaine and adrenaline can be used for local or regional anaesthesia for dental procedures. Anaesthesia begins within six minutes and lasts for an hour. The half-life of articaine is approximately 1.8 hours. It is metabolised and then mainly excreted in the urine.

  • Clinical use

(1) Articaine is used for pain control. Like other local anesthetic drugs, articaine causes a transient
and completely reversible state of anesthesia (loss of sensation) during (dental) procedures.
(2) In dentistry, articaine is used both for infiltration and block injections, with the block technique
yielding the greatest duration of anesthesia.
(3) In people with hypokalemic sensory overstimulation, lidocaine is not very effective, but articaine
works well.

 

Product Name Articaine hydrochloride
Synonyms Articaine hydrochloride [USAN]; 2-Thiophenecarboxylic acid, 4-methyl-3-((1-oxo-2

-(propylamino)propyl)amino)-, methyl ester, monohydrochloride; 4-Methyl-3-(2-

(propylamino)propionamido)-2-thiophenecarboxylic acid methyl ester HCl; Articaine HCl; Articaine hydrochloride;

Carticaine hydrochloride; HOE 045; HOE 40045; Methyl 4-methyl-3-(2-(propylamino)propionamido)-2-thiophenecarboxylate, monohydrochloride; Septanest; Septocaine; UNII-QS9014Q792; Ultracain; Ultracaine; 2-Thiophenecarboxylic acid, 4-methyl-3-(2-(propylamino)propionamido)-, methyl ester, monohydrochloride; Methyl 4-methyl-3-((1-oxo-2-(propylamino)propyl)amino)-2-thenoate monohydrochloride; methyl 4-methyl-3-[(N-propylalanyl)amino]thiophene-2-carboxylate hydrochloride (1:1)

Molecular Formula C13H21ClN2O3S
Molecular Weight 320.8354
CAS Registry Number 23964-57-0
EINECS 245-957-7
Boiling point 440.6°C at 760 mmHg
Flash point 220.3°C
Vapour Pressure 5.79E-08mmHg at 25°C

 

 

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