Diethylstilbestrol CAS 56-53-1;6898-97-1

01 Overview

Diethylstilbestrol (DES, former BAN stilboestrol) is a synthetic nonsteroidal estrogen that was first synthesized in 1938. It is also classified as an endocrine disruptor.

02 Details

High Purity Raw Steroid Powders Diethylstilbestrol CAS 56-53-1 for Estrogen

 

Diethylstilbestrol

Product Name: Diethylstilbestrol
Synonyms: LABOTEST-BB LT00233101;DIETHYLSTILBESTEROL;DOMESTROL;GRAFESTROL;ESTROSYN;FONATOL;ALPHA;ALPHA,ALPHA’-DIETHYL-(E)-4,4′-STILBENEDIOL
CAS: 56-53-1
MF: C18H20O2
MW: 268.35
EINECS: 200-278-5

Chemical Properties White Solid
Usage A synthetic, nonsteroidal estrogen. Recomended solvents are DMSO, DMF and ethanol, even in these solvents do not store in solution for any prolonged period of time.
General Description Odorless tasteless white crystalline powder.
Air & Water Reactions Insoluble in water.
Reactivity Profile Diethylstilbestrol is incompatible with strong oxidizing agents, strong bases, acid chlorides and acid anhydrides .
Fire Hazard Flash point data for Diethylstilbestrol are not available; however, Diethylstilbestrol is probably combustible.

 

Diethylstilbestrol Description:

 

Diethylstilbestrol (DES, former BAN stilboestrol) is a synthetic nonsteroidal estrogen that was first synthesized in 1938. It is also classified as an endocrine disruptor. Human exposure to DES occurred through diverse sources, such as dietary ingestion from supplemented cattle feed and medical treatment for certain conditions, including breast and prostate cancers. From about 1940 to 1971, DES was given to pregnant women in the mistaken belief it would reduce the risk of pregnancy complications and losses.

 

In 1971, DES was shown to cause a rare vaginal tumor in girls and women who had been exposed to this drug in utero. The United States Food and Drug Administration subsequently withdrew DES from use in pregnant women. Follow-up studies have indicated that DES also has the potential to cause a variety of significant adverse medical complications during the lifetimes of those exposed.The United States National Cancer Institute recommends women born to mothers who took DES undergo special medical exams on a regular basis to screen for complications as a result of the drug. Individuals who were exposed to DES during their mothers’ pregnancies are commonly referred to as “DES daughters” and “DES sons”.

 

Diethylstilbestrol Specification:
Test Items  

Specification

 

Test Results

 

Properties

 

A white or almost crystal powders

 

Almost white crystal powders

 

Identification

 

Positive

 

Complies

 

Acid Basicity

 

Neutrality is reacted

 

Complies

 

Content

≥98% 99.29%
 

Melting point

169~172℃ 170~172℃
 

Related substance

≤0.5%  

Complies

 

Loss on drying

≤0.5% 0.2%
Organic volatile impurities  

Complies

 

Complies

 

Sulphated ash

≤0.1% 0.02%

 

 

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Estradiol Estrone Hydrocortisone
Estradiol valerate Estriol Hydrocortisone acetate
Estradiol benzoate Nylestriol Meprednisone
Estradiol cypionate Diethylstilbestrol Prednisone acetate
Estradiol enantate HEXESTROL Bentelan
Ethynyl estradiol Progesterone Betamethasone
Algestone acetophenide Medroxyprogesterone acetate Clobetasol propionate
Ethisterone Norethindrone Halobetasol propionate
19-Norethindrone acetate Mifepristone Deflazacort
Norethisterone Enanthate Methyldienedione Tazarotene
Ethynodiol diacetate Eplerenone Ecdysone
Pregnenolone acetate Levonorgestrel Desloratadine
Lynestrenol Allylestrenol Prednisolone phosphate sodium
Chlormadinone acetate Dienogestrel Fluorometholone Acetate
Cyproterone acetate Drospirenone Dexamethasone Acetate
Megestrol acetate Pregnenolone Dexamethasone Sodium Phosphate
Melengestrol acetate Mometasone furoate Dexamethasone palmitate
Betamethasone acetate Beclomethasone dipropionate Fluocinolone acetonide
Betamethasone Dipropionate Betamethasone 17-valerate

 

 

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