Estradiol CAS 50-28-2
01 Overview
Estradiol is the most important hormone during a female’s reproductive years, and is required for reproductive and sexual function as well as having an impact on the health of other organs and tissues.
02 Details
Natural Female Hormone Powder Anti Estrogen Steroids 17a-Estradiol CAS 50-28-2
Estradiol
Product Name: Estradiol
Synonyms: BETA-ESTRADIOL-16,16,17-D3;17BETA-ESTRADIOL-16,16,17-D3;(+)-3,17β-estradiol;(17b)-estra-1,3,5(10)-triene-3,17diol;(17β)-estra-1,3,5(10)-triene-3,17diol;.alpha.-Oestradiol;.beta.-Oestradiol;17-.beta.-Estra-1,3,5(10)-triene-3,17-diol
CAS: 50-28-2
MF: C18H24O2
MW: 272.38
EINECS: 200-023-8
Chemical Properties White Crystalline Powder
Usage Potent mammalian estrogenic hormone produced by the ovary.
Usage Estradiol is the major estrogen secreted by the premenopausal ovary.
Biological Activity Endogenous estrogen receptor (ER) agonist (K i values are 0.12 and 0.13 nM for ER α and ER β respectively). Also high affinity ligand at membrane estrogen GPR30 receptors.
Estradiol details:
(1) Estradiol being a sex hormone. With alpha, beta, two types of alpha physiological function is strong. Steiner, winter was extracted from the horse urine pregnancy, moreover also can cause from the urine, placenta, pig ovary, etc. There is also a male horse testis or urine. Because it has the very strong sex role, so that it or its ester is, in fact, ovarian secretion of the sex hormones of the most important. Estradiol benzoate is decided to one of the international unit of sex hormone titer standard substance and used.
Estradiol is a sex hormone that is present in both males and females, and is the most important form of estrogen in humans. In women, it plays a key role in the development and functioning of the reproductive system, as well as in the growth of certain bones. It also governs the distribution of body fat in women and is the main hormone responsible for the fact that women are shorter than men, on average. Both the ovaries and the adrenal glands produce it.
(2)The menstrual cycle in women involves predictable variations in the levels of several hormones, with estradiol being one of them. It is involved in the ovulation process and prepares the inner lining of the uterus for implantation, should the egg be fertilized. Certain tests done on baboons and other primates have indicated that his hormone also plays a continual role in maintaining a pregnancy, helping it to last for the full gestation period.
Estrogen drugs. Used for functional uterine bleeding, primary amenorrhea, menopause syndrome, prostate cancer. To promote and regulate women’s genitals and secondary normal development. Can cause hyperplasia of mammary gland carcinoma development, but in larger doses, can inhibit pituitary prolactin release, and reduce the secretion of milk. Can also be used for milk. But there may be nausea, vomiting and endometrial hyperplasia of excessive bleeding, etc. Liver and renal insufficiency with caution. Avoid is used for breast, vulva and vaginal mucosa.
Estradiol (o) estradiol C18H24O2 being a sex hormone. With alpha, beta, two types of alpha physiological function is strong. Steiner, winter (Wintersteiner et al. 1935) was extracted from the horse urine pregnancy, moreover also can cause from the urine, placenta, pig ovary, etc. There is also a male horse testis or urine. Because it has the very strong sex role, so that it or its ester is, in fact, ovarian secretion of the sex hormones of the most important. Estradiol benzoate is decided to one of the international unit of sex hormone titer standard substance and used.
Estradiol Function:
Function and use: It is a kind of estrogen, can promote and regulate the normal development of women’s genitals and secondary. Can cause hyperplasia of mammary gland carcinoma development, but in larger doses, can inhibit pituitary prolactin release, and reduce the secretion of milk. Potent mammalian estrogenic hormone produced by the ovary.
COA
| Product name | Estradiol | |
| Appearance | White crystalline powder | |
| Characteristics | White or creamy white, crystalline powder | conform |
| Melting point | 173 ~ 179°C | 178~ 179°C |
| Specific rotation | +76°~+83° | +78.5° |
| Water | ≤3.5% | pass |
| Assay | 97 .0~ 103.0% | 99.07% |
| Loss on drying | ≤0.5% | 0.21% |
| Related substances | total impurities ≤1.0% | Pass |
| any individual impurity ≤0.5% | Pass | |
| Residual solvents | ethanol ≤0.5% | Pass |
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