Estrone CAS 53-16-7
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1. Brief Introduction:
English Synonyms: (8R,13S)-3-Hydroxy-13-methyl-6,7,8,9,11,12,13,14,15,16-decahydro-cyclopenta[a]phenanthren-17-one;1,3,5(10)-Oestratrien-3-ol-17-one;1,3,5-Oestratrien-3-ol-17-one;3-Hydroxy-1,3,5-(10)-oestratrien-17-one;3-Hydroxy-1,3,5(10)-oestratrien-17-one;3-hydroxy-17-keto-estra-1,3,5-triene;3-Hydroxy-17-ketoestra-1,3,5-triene;3-hydroxy-17-keto-oestra-1,3,5-triene
CAS NO.: 53-16-7
Quality Standard: USP31
Usage: Synthesis of pharmaceutical intermediates is ethinyl estradiol
Estrone (E1, and also oestrone) is an estrogenic hormone secreted by the ovary as well as adipose tissue with the chemical name of 3-hydroxyestra-1,3,5(10)-triene-17-one and the chemical formula C18H22O2. Estrone is an odorless, solid crystalline powder, white in color with a melting point of 254.5 °C and a specific gravity of 1.23. Estrone is one of several natural estrogens, which also include estriol and estradiol. Estrone is the least abundant of the three hormones; estradiol is present almost always in the reproductive female body, and estriol is abundant primarily during pregnancy.
Estrone is known to be a carcinogen for human females as well as a cause of breast tenderness or pain, nausea, headache, hypertension, and leg cramps in the context of non-endogenous exposure. In men, estrone has been known to cause anorexia, nausea, vomiting, and erectile dysfunction Estrone is relevant to health and disease states because of its conversion to estrone sulfate, a long-lived derivative. Estrone sulfate acts as a reservoir that can be converted as needed to the more active estradiol. It is the predominant estrogen in postmenopausal women.
Estrone has been proven to be a known carcinogen for human females. The Occupational Safety and Health Administration (OSHA) classifies estrone as an OSHA Select carcinogen. Exposure to estrone can cause breast tenderness or pain, cervical hyper secretion, menstrual disorders including menorrhagia and metrorrhagia, nausea, headache, hypertension, leg cramps, vision disturbances, and endometriosis pain in women. Mothers lactating can also experience a decrease in the production of breast milk. Estrone can be found in the urine of pregnant women and can also be excreted in feces.
Exposure to estrone can cause anorexia, nausea, vomiting, edema, feminization including gynecomastia and erectile dysfunction in men.
If exposure of estrone to the eyes occurs, contacts should be removed and rinsed with water for 15 minutes. If any irritation occurs medical attention may be necessary. Exposure of estrone to the eyes can be prevented through the use of safety goggles.
If exposure of estrone to the skin occurs, the effected area should be washed with soap and water and then covered with an emollient or moisturizer. Medical attention may be necessary if irritation persists. Exposure of estrone can be prevented through the use protective gloves, the wearing of pants, shirts that cover the entire upper body, and lab coat.
|Description||White or almost white crystalline powder||White crystalline powder|
|Loss of drying||≤1.0%||0.5%|
|TLC||Only one spot||Only one spot|
|Conclusion||It complies with the USP 32.|
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