Finasteride CAS 98319-26-7

02 Details

Crystalline Hair Loss Treatment Finasteride Propecia Steroid Raw Powder CAS 98319-26-7

 

 

Quick Detail:
product name: Finasteride
Brand names Proscar and Propecia
MF: C23H36N2O2
MW: 372.55
CAS Number: 98319-26-7
Finasteride content: 99%
Quality standard: USP31/EP5
Packing: as your reuire
Appearance: off-white crystalline powder
Storage: Stored and protected from light.

 

Description:

 

Propecia (finasteride) is used to treat male pattern baldness (androgenic alopecia) in men. Oral use though will reduce DHT levels systemically, which may adversely affect training and sex drive.

 

It is also used in combination with doxazosin in the treatment of benign prostatic hyperplasia (BPH).] Finasteride is an orally active testosterone Type II 5-alpha reductase inhibitor, inhibiting the enzyme that converts testosterone to dihydrotestosterone (DHT).

 

Topically (on the scalp itself) it is of some effect in minimizing further hair loss. In combination with Nizoral and spironolactone (which smells awful, by the way) it can actually reverse loss moderately.

 

For use in cycles with testosterone, I don’t think it is bad at all. One simply doesn’t want less DHT than normal. As the amount of testosterone in the system increases, the amount of finasteride needed to keep levels down to normal increases. I consider 5 mg/day reasonable at the gram per week level, and proportionally less at lower dosages of testosterone.

 

 

Medical uses:

 

(1) Benign prostatic hyperplasia:

 

Physicians use finasteride for the treatment of benign prostatic hyperplasia (BPH), informally known as an enlarged prostate. The FDA-approved dose is 5 mg once a day. Six months or more of treatment with finasteride may be required to determine the therapeutic results of treatment. If the drug is discontinued, any therapeutic benefits reverse within about 6–8 months. Finasteride may improve the symptoms associated with BPH such as difficulty urinating, getting up during the night to urinate, hesitation at the start of urination, and decreased urinary flow.

 

(2) Male pattern baldness:

 

Three Phase 3 clinical trials examined the efficacy of finasteride in the treatment of mild to moderate male pattern baldness. The primary endpoints of each trial were hair count and user self-assessment. Secondary endpoints included investigator assessment and examination of scalp photographs. Each patient also filled out questionairres regarding sexual health and non-scalp body hair growth. These trials enrolled 1879 men and had a duration of one year. Of these 1879 men, 1215 elected to participate in a one year double blind extension trial. Additional extension trials were performed such that 323 men experienced over 4 years of treatment.

 

Across all three trials, at one year men taking Propecia had 107 more hairs per 1 inch diameter section of scalp (in the area affected by hair loss) than men treated with placebo. At two years the difference was 138 hairs. Maximum hair gain occurred during the first two years, but because hair loss was more rapid in the placebo treated group, the difference between treated and placebo groups increased to 277 hairs per inch circle at 5 years. Self assessment showed that treated patients perceived an improvement in hair density and overall appearance. These results were supported by investigator ratings and by independent readers examining scalp photographs.

 

At the end of the first year, the sexual health questionaire revealed differences in sexual interest, erections, and perception of sexual problems that favored the placebo group. However, no significant difference was seen in the question on overall satisfaction with sex life.

 

 

Off-label uses:

 

Finasteride is sometimes used in hormone replacement therapy for male-to-female transsexuals in combination with a form of estrogen due to its antiandrogen properties.[5][6] However, little clinical research of finasteride use for this purpose has been conducted and evidence of efficacy is limited. Indeed, finasteride is a substantially weaker antiandrogen in comparison to conventional antiandrogens like spironolactone and cyproterone acetate.

 

 

Applications:

 

Propecia (finasteride) is used to treat male pattern baldness (androgenic alopecia) in men. Topically (on the scalp itself) it is of some effect in minimizing further hair loss. In combination with Nizoral and spironolactone (which smells awful, by the way) it can actually reverse loss moderately.

Used for the treatment of prostate disease first. Clinical studies suggest that, with finasteride 1 mg/day, continuous oral 3 months or slightly long can have hair growth, after continuous treatment 1 year hair growth rate to 48%, and can continue to fall off, taking the hair organization 2 years hair growth rate reached 66% ~ 83%.

 

 

Specifications:

 

Test Items	Specification		Test Results
Description	White or off-white crystalline powder		Off-white crystalline powder
Specific rotation	-56°~-60°		-58.2°
Identification	IR	Matches with working standard	Complies
	HPLC
Solubility	Freely soluble in chloroform and in alcohol; Very slightly soluble in water		Conform
Heavy metals	≤10ppm		＜10ppm
Water	≤0.3%		0.22%
Residue on ignition	≤0.1%		0.05%
Relative material	Maximum impurities≤0.5%		0.36%
	Total impurities≤1.0%		0.52%
Assay	98.5~101.0%		99.68%
Conclusion	The specification conform with USP29

 

 

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