Letrozole (Femara / Formestane) CAS 112809-51-5
01 Overview
Female hormones that occur naturally in the body can increase the growth of some breast cancers. Letrozole works by decreasing the amounts of these hormones in the body.
letrozole-2
Letrozole02 Details
Medication Femara Letrozole Bodybuilding Natural Anti Estrogen Supplements For Men 112809-51-5
Quick Detail:
| Product name | Letrozol |
| Other name | Femara |
| CAS | 112809-51-5 |
| MF | C17H11N5 |
| MW; | 285.3 |
| Usage | Used as API in Treatment of breast disease. |
| Assay | 99% |
| Appearance: | White Powder |
| Skype | josiesteroids |
| Whatsapp: | +8613168027820 |
Description:
Letrozole is approved by the United States Food and Drug Administration (FDA) for the treatment of local or metastatic breast cancer that is hormone receptor positive or has an unknown receptor status in postmenopausal women.Letrozole is intended for use only by women who are no longer of childbearing age. Possible candidates must have already ceased to menstruate. It is often used in patients who have already undergone other cancer treatments, such as radiation, chemotherapy, and used other cancer drugs, like tamoxifen. This nonsteroidal aromatase inhibitor may help prevent any remaining cancer cells from spreading.
Femara is used for the treatment of post-menopause breast cancer. Femara is a powerful Aromatase Inhibitor that was developed to fight breast cancer. For athletes and bodybuilders, it is a drug used to combat the estrogenic side effects of anabolic steroids water-retention, acne and gynocomastia. It will also raise testosterone levels because of the lowered estrogen in the body. Side effects from include a lowered sex drive and continuous use can lead to lowered lipid function and an impaired immune system.
Applications:
Letrozole has been used for ovarian stimulation by fertility doctors since 2001 because it has fewer side-effects than clomiphene (Clomid) and less chance of multiple gestation. A Canadian study presented at the American Society of Reproductive Medicine 2005 Conference suggested that letrozole may increase the risk of birth defects.[citation needed] A more detailed ovulation induction follow-up study found that letrozole, compared with a control group of clomiphene, had significantly lower congenital malformations and chromosomal abnormalities at an overall rate of 2.4% (1.2% major malformations) compared with clomiphene 4.8% (3.0% major malformations). Despite this, India banned the usage of letrozole in 2011, citing potential risks to infants.In 2012, an Indian parliamentary committee said that the drug controller office colluded with letrozole’s makers to approve the drug for infertility in India and also stated that letrozole’s use for infertility was illegal worldwide; however, such off-label uses are legal in many countries such as the US and UK.
The anti-estrogen action of letrozole has been shown to be useful in pretreatment for termination of pregnancy, in combination with misoprostol. It can be used in place of mifepristone, which is expensive and unavailable in many countries.
Letrozole is sometimes used as a treatment for gynecomastia, although it is probably most effective at this if caught in an early stage (such as in users of anabolic steroids).
Letrozole has also been shown to delay the fusing of the growth plates in mice.When used in combination with growth hormone, letrozole has been shown effective in one adolescent boy with a short stature.
Usage:
Letrozole(Femara )is a powerful Aromatase Inhibitor that was developed to fight breast cancer. For athletes and bodybuilders, it is a drug used to combat the estrogenic side effects of anabolic steroids water-retention, acne and gynocomastia. It will also raise testosterone levels because of the lowered estrogen in the body. Side effects from Femara include a lowered sex drive and continuous use can lead to lowered lipid function and an impaired immune system.
COA:
| Tests | Specifications | Results |
| Appearance | White or off-white crystaline powder | White Crystalline powder |
| Solubility | Soluble in Chloroform; Soluble in ethanol when heated |
Conform |
| ldentification | (1)Maximum absorption in wavelength of 240 nm Minimum absorption in wavelength of 215 nm |
Conform Conform |
| (2)Infrared spectrum should be in accordance the dominant peak of contrast |
In accordance with the dominant peak of contrast |
|
| Melting points | 182ºC-184ºC | 182ºC |
| Related substances | ≤0.5% | 0.3% |
| Single impurity | ≤0.3% | 0.2% |
| Loss on drying | ≤1.0% | 0.8% |
| [Assay] | ≥98.0% | 99.2% |
| Conclusion | Conforms Specifications of Enterprise Standard. | |
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