Lidocaine Base CAS 137-58-6
01 Overview
Lidocaine, xylocaine, or lignocaine is a common local anesthetic and class-1b antiarrhythmic drug. Lidocaine is used topically to relieve itching, burning, and pain from skin inflammations, injected as a dental anesthetic, or as a local anesthetic for minor surgery.
lidocaine-base
Lidocaine02 Details
Lidocaine Base CAS 137-58-6 Pharmaceutical Raw Materials Topical Anesthetic And Treatment
1. Lidocaine Base Details:
Name: Lidocaine Base
Synonyms:Xylocaine; 2-(Diethylamino)-2′,6′-acetoxylidide;2-(diethylamino)-2’,6’-acetoxylidide;
2-(diethylamino)-n-(2,6-dimethylphenyl)-acetamid;2′,6′-Acetoxylidide, 2-(diethylamino)-;
6’-acetoxylidide,2-(diethylamino)-2;Acetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl)-;
Acetamide,2-(diethylamino)-N-(2,6-dimethylphenyl)-;a-Diethylamino-2,6-acetoxylidide
CAS: 137-58-6
MF: C14H22N2O
MW: 234.34
EINECS: 205-302-8
Molecular Structure:
Product Categories:Research Chemical;Alphacaine, Xylocaine, lignocaine
Chemical Properties: white solid
Usage:Lidocaine (Alphacaine)is a selective ainverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM.
Packaging Details: 25kg/drum or as required
Shelf Life 24 months
Storage Store in sealed containers at cool & dry place. Protect from light, moisture and pest infestation.
2. Lidocaine Base COA:
| Items | Claims | Results |
| Appearance | White crystalline powder | Pass |
| Content Wt. | 99.00%-101.00% | 99.72% |
| Identification | Chloridate | Positive |
| Test A | Positive | |
| Melting point | 74-79ºC | 75.8-77.3ºC |
| Appearance of solution | Clear and colourless | Pass |
| Water | 5.5-7.0% | 5.8% |
| Acidity PH | 4.0-5.5 | 5.3 |
| Sulphated ash | 0.10% max | 0.06% |
| Heavy metals | 5ppm max | Pass |
| 2, 6-Dimethylaniline | 100ppm max | Pass |
| Sulfate | Meet the requirement | Pass |
| Conclusion | Qualified | |
3. Lidocaine Base Application:
A- For block anesthesia and epidural anesthesia.
B- Also used for ventricular arrhythmias caused by myocardial infarction, digitalism, glucantime poisoning, surgery and so on. Such as ventricular tachycardia, frequent ventricular premature beat, ventricular fibrillation.
C- As painkillers of injection in the medicament.
D- Also used in suppository and ointment preparation, etc.
4. Lidocaine Base Description:
Lidocaine, xylocaine, or lignocaine is a common local anesthetic and class-1b antiarrhythmic drug. Lidocaine is used topically to relieve itching, burning, and pain from skin inflammations, injected as a dental anesthetic, or as a local anesthetic for minor surgery.It is on the World Health Organization’s List of Essential Medicines, a list of the most important medications needed in a basic healthcare system.
Lidocaine is the most important class-1b antiarrhythmic drug; it is used intravenously for the treatment of ventricular arrhythmias (for acute myocardial infarction, digoxin poisoning, cardioversion, or cardiac catheterization) if amiodarone is not available or contraindicated. Lidocaine should be given for this indication after defibrillation, CPR, and vasopressors have been initiated. A routine prophylactic administration is no longer recommended for acute cardiac infarction; the overall benefit of this measure is not convincing.
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