Lidocaine Hydrochloride CAS 73-78-9
Lidocaine hydrochloride is a white powder without smell and with a bitter taste that is used both in human and veterinary medicine. The drug is also known as lignocaine hydrochloride, and is used as a local anesthetic and to regulate certain medical problems related to heart rhythm.
Local Anesthetic Drugs Lidocaine Hydrochloride / Lidocaine HCL CAS 73-78-9 Pharmaceutical Steroids Powder
Product name: Lidocaine Hydrochloride
Other name: Lidocaine HCL, Lidocaine, Lidocaine Base
Melting point: 350.8° C at 760 mmHg
Usage: Local anesthetics, antiarrhythmic drugs, used for a variety of anesthesia and rapid ventricular arrhythmia
Lidocaine hydrochloride is a white powder without smell and with a bitter taste that is used both in human and veterinary medicine. The drug is also known as lignocaine hydrochloride, and is used as a local anesthetic and to regulate certain medical problems related to heart rhythm. Injections of it are used to provide local anesthesia during various minor surgical procedures. It is also available in various topical preparations, such as gels, sprays, creams, and ointments that are usually applied to the skin or the mucous membranes. This drug was first manufactured in Sweden in 1943 and was then named xylocaine.
Lidocaine may be absorbed following topical administration to mucous membranes, its rate and extent of absorption depending upon concentration and total dose administered, the specific site of application, and duration of exposure. In general, the rate of absorption of local anesthetic agents following topical application occurs most rapidly after intratracheal administration. Lidocaine is also well-absorbed from the gastrointestinal tract, but little intact drug may appear in the circulation because of biotransformation in the liver.
Lidocaine is metabolized rapidly by the liver, and metabolites and unchanged drug are excreted by the kidneys. Biotransformation includes oxidative N-dealkylation, ring hydroxylation, cleavage of the amide linkage, and conjugation. N-dealkylation, a major pathway of biotransformation, yields the metabolites monoethylglycinexylidide and glycinexylidide.
The plasma binding of lidocaine is dependent on drug concentration, and the fraction bound decreases with increasing concentration. At concentrations of 1 to 4 mcg of free base per mL, 60 to 80 percent of lidocaine is protein bound. Binding is also dependent on the plasma concentration of the alpha-1-acid glycoprotein.
A- For block anesthesia and epidural anesthesia.
B- Also used for ventricular arrhythmias caused by myocardial infarction, digitalism, glucantime poisoning, surgery and so on. Such as ventricular tachycardia, frequent ventricular premature beat, ventricular fibrillation.
C- As painkillers of injection in the medicament.
D- Also used in suppository and ointment preparation, etc.
|Product name||Lidocaine Hydrochloride|
|Appearance||White crystalline powder|
|Assay (C13H20N2O2·HCl)||99.0% to 101.0%||99.75%|
|Solution Appearance||Clear and colorless||Confirm|
|Related impurities||impurity A:≤0.01%||0.002%|
|Single unspecified impurity: ≤0.1%||0.02%|
|Total impurity: ≤0.5%||0.20%|
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