Megestrol Acetate CAS 595-33-5
01 Overview
Megestrol acetate is used mainly as an appetite stimulant in a variety of conditions and as an antineoplastic agent in the treatment of breast, endometrial, and prostate cancers. When given in relatively high doses, it can substantially increase appetite in most individuals, even those with advanced cancer, and is often used to boost appetite and induce weight gain in patients with cancer or HIV/AIDS-associated cachexia.
megestrol-acetate-1
Megestrol acetate02 Details
99% Purity SERMs Steroids Megestrol Acetate CAS 595-33-5 For Appetite Stimulant
Basic info
Product Name: Megestrol acetate
Synonyms: 17-(acetyloxy)-6-methylpregna-4,6-diene-3,20-dione;17-Acetoxy-6-methylpregna-4,6-diene-3,20-dione;17-alpha-acetoxy-6-dehydro-6-methylprogesterone;17alpha-Acetoxy-6-dehydro-6-methylprogesterone;17-Hydroxy-6-methylpregna-4,6-diene-3,20-dione17-acetate;5071;6-dehydro-6-methyl-17-alpha-acetoxyprogesterone;6-Dehydro-6-methyl-17alpha-acetoxyprogesterone
CAS: 595-33-5
MF: C24H32O4
MW: 384.51
EINECS: 209-864-5
Specification
| Test Items | Specification | Test Results |
| Appearance | White to creamy white crystalline powder | White crystalline powder |
| Identification | IR | Complies |
| Completeness of solution | Meets the requirements.500mg being | Complies |
| dissolved in 10ml of acetone | ||
| Solubility | Insoluble in water, sparingly soluble in | Complies |
| alcohol. Slightly soluble in ether and in | ||
| fixed oils, soluble in acetone; very soluble | ||
| in chloroform. | ||
| Melting range | 213ºC~220ºC | 217ºC |
| Specific optical rotation | +8.8°~ +12.0° | +11.6° |
| Water | ≤0.5% | 0.1% |
| Residue roration | ≤0.2% | 0.06 |
| Heavy metals | ≤0.002% | Complies |
| Assay | 97.0%~103.0% | 99.6% |
| Residual solvents | Methanol≤1000ppm | 74ppm |
| Ethanol≤1000ppm | 39ppm | |
| Methylene chloride≤500ppm | 28ppm | |
| Tetrahydrofuran≤300ppm | ND | |
| Benzene≤2ppm | ND |
Applicatiom
Megestrol acetate is used mainly as an appetite stimulant in a variety of conditions and as an antineoplastic agent in the treatment of breast, endometrial, and prostate cancers. When given in relatively high doses, it can substantially increase appetite in most individuals, even those with advanced cancer, and is often used to boost appetite and induce weight gain in patients with cancer or HIV/AIDS-associated cachexia. It is also used as a contraceptive in combination with an estrogen at relatively low doses.
Megestrol acetate Powder Description:
Megestrol acetate has powerful antiandrogenic and antiestrogenic effects in humans at sufficient doses, capable of decreasing circulating androgen and estrogen concentrations to castrate levels in both sexes and significantly lowering the expression of the androgen receptor (AR) and the estrogen receptor (ER) in the body.
As an example, one study in men with benign prostatic hyperplasia who were treated with 120-160 mg of megestrol acetate per day for 3 to 11 days found average decreases in AR quantity of 73% and 86% in the cytoplasm and nucleus of prostatic cells.
These actions are likely the result of a strong activation of the PR, which suppresses the secretion of the gonadotropins-peptide hormones responsible for signaling the body to produce not only progesterone but also the androgens and the estrogens-from the pituitary gland as a form of negative feedback inhibition.
And hence downregulates the hypothalamic-pituitary-gonadal (HPG) axis, resulting in decreased levels of the sex hormones and their associated enzymes, carriers (e.g., sex hormone-binding globulin), and receptors.
It is the antiandrogenic and antiestrogenic effects of megestrol acetate mediated by suppression of the HPG axis that are believed to be largely responsible for its beneficial effects against androgen and estrogen-sensitive cancers, respectively.
Function:
(1)Orally active progesteron with antiandrogenic activity;
(2)Has been used in combinations as an oral contraceptive. Progestogen;
(3)Antineoplastic (hormonal)
Company Introduction:
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