Melengestrol Acetate CAS 2919-66-6
Melengestrol (INN, BAN) is a steroidal progestin and antineoplastic agent which was never marketed.An acylated derivative, melengestrol acetate, is used as a growth promoter in animals Progestogens are synthetic forms of the naturally occurring hormone, progesterone.
Effective Antiarrhythmic Medications Melengestrol Acetate Cattle CAS 2919-66-6
Product Name: Melengestrol acetate
Synonyms: 20-dione,17-(acetyloxy)-6-methyl-16-methylene-pregna-6-diene-3;6-dehydro-16-methylene-6-methyl-17-acetoxyprogesterone;6-diene-3,20-dione,17-hydroxy-6-methyl-16-methylene-pregna-acetate;bdh1921;mga100;mga100(steroid);4,6-PREGNADIEN-6-METHYL-16-METHYLENE-17-OL-3,20-DIONE ACETATE;17ALPHA-ACETOXY-6-METHYL-16-METHYLENE-4,6-PREGNADIENE-3,20-DIONE
Chemical Properties Light Tan Solid
Usage antiarrhythmic, cardiotonic, hypertensive, Na/K ATPase inhibitor
Usage Orally active progestational steroid. Progestogen; growth promotant.
Melengestrol Acetate Description:
Melengestrol (INN, BAN) is a steroidal progestin and antineoplastic agent which was never marketed.An acylated derivative, melengestrol acetate, is used as a growth promoter in animals
Progestogens are synthetic forms of the naturally occurring hormone, progesterone. Progesterone is produced by the corpus luteum . By negative feedback, it reduces pituitary function, thus preventing a female from coming into heat. When administered in conjunction with a luteolytic agent, such as PGF2a or estradiol valerate, progestogens can provide an effective means of resetting the cow’s physiological clock. If the progestogen is administered for several days, an artificial corpus luteum can in effect be installed, which can be removed at the producer’s discretion.
Melengestrol Acetate Specification:
|Description||Light Yellow crystalline powder,odorless||Conforms|
|Solubility||Easily soluble in water, unsoluble in ethanol||Conforms|
|Solution clarity and color||solution should be clear and colorless||Conforms|
|Related substances||5’CMP 0.3%
Total other impurity
|Loss on drying||≤6.0%||1.30%|
|Assay(on dried basis)||≥98.0%||99.50%|
|Conclusion: The results conform with CP2013|
To investigate the relation of ovarian morphology to increased body weight gain during administration of melengestrol acetate, ovaries of 100 Holstein dairy heifers were examined for characteristics of follicular maturation, signs of lipid secretion, and the presence of steroid-producing-type cell organelles. The heifers were fed either a normal or a high-protein level ration with or without 0.30–0.45 mg daily of MGA from 2.5 months of age to the age of first estrus or to breeding age. The high-level ration effect was not consistently mediated by the special development of ovarian structures.
MGA effect, like the weight-gain effect, was consistently evident after the time of first estrus. MGA suppressed estrus and ovulation, and resulted in the presence in the ovary, after regression of corpora lutea, of an increased number of large follicles. The largest follicles corresponding in structure to developing proestrous, mature estrous, or early atretic follicles contained hypertrophied theca interna cells showing lipid secretion signs and ultrastructural characteristics of steroid synthesis. The majority of the largest follicles, however, were atretic or late atretic and did not contain steroid-type cells. The development of replacement follicles was evident in ovaries with late atretic largest follicles. The weight-gain effect of MGA may therefore be associated with a steroidogenic, probably estrogenic, effect in the cow.
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