Procaine Hydrochloride CAS 51-05-8

01 Overview

Procaine HCl is a local anesthetic drug of the amino ester group. It is used primarily to reduce the pain of intramuscular injection of penicillin, and it is also used in dentistry. Owing to the ubiquity of the trade name Novocain, in some regions procaine is referred to generically as novocaine.

02 Details

Local Anesthetic Powder USP Standard 99.5% 51-05-8 Procaine Hydrochloride, Procaine HCL

 

Quick Details:

 

  • Product name: Procaine HCl
  • Alias: Procaine hydrochloride;aminocaine;anadolor;atoxicocaine;
  • CAS register number: 51-05-8
  • Assay: 99%
  • EINECS: 200-077-2
  • Grade: Pharmaceutical Grade
  • Storage: Shading, confined preservation
  • Appearance: White crystalline powder
  • Manufacturer: Hezhong
  • Usage: Procaine hydrochloride is a kind of local anesthetics, for local anesthesia, nerve block etc, can block the conduction of nerve fibers with anesthetic effect, strong function, low toxicity, and no addiction, but the skin, mucous membrane penetration force is weak, not suitable for surface anesthesia, clinically used to infiltration, spine and conduction anesthesia.

 

Product Description:

 

Molecular formula: C13H21ClN2O2

Molecular weight: 272.77

Molecular structure

Pharmaceutical Raw Materials Procaine Powder Procaine hydrochloride 99% CAS 51-05-8 for Anti-inflammatory

Melting point: 155-156 °C

 

Application:

 

Procaine HCl is a local anesthetic drug of the amino ester group. It is used primarily to reduce the pain of intramuscular injection of penicillin, and it is also used in dentistry. Owing to the ubiquity of the trade name Novocain, in some regions procaine is referred to generically as novocaine. It acts mainly by being a sodium channel blocker.Today it is used therapeutically in some countries due to its sympatholytic, anti-inflammatory, perfusion enhancing, and mood enhancing effects.

 

Procaine HCl is indicated for the production of local or regional analgesia and anesthesia by local infiltration and peripheral nerve block techniques.

 

Application of procaine leads to the depression of neuronal activity. The depression causes the nervous system to become hypersensitive producing restlessness and shaking, leading to minor to severe convulsions. Studies on animals have shown the use of procaine led to the increase of dopamine and serotonin levels in the brain.Other issues may occur because of varying individual tolerance to procaine dosage. Nervousness and dizziness can arise from the excitation of the central nervous system, which may lead to respiratory failure if overdosed. Procaine may also induce weakening of the myocardium leading to cardiac arrest.

 

Procaine can also cause allergic reactions causing the individuals to have problems with breathing, rashes, and swelling. Allergic reactions to procaine are usually not in response to procaine itself, but to its metabolite PABA. About one in 3000 people have an atypical form of pseudocholinesterase,[citation needed] which does not hydrolyze ester anesthetics such as procaine, resulting in a prolonged period of high levels of the anesthetic in the blood and increased toxicity.

 

COA :

 

Product name Procaine HCl
Appearance White crystalline powder
Assay (C13H20N2O2·HCl) 99.0% to 101.0% 99.5%
Melting point 153~158℃ 156.5~157.0℃
Heavy metals ≤20ppm <5ppm
Acidity ≤0.02N NaOH 0.5ml 0.3ml
Chromatographic purity Secondary spots≤0.5%,sum≤1.0% Conforms
Loss on drying ≤1.0% 0.06%
Residue on ignition ≤0.15% 0.03%
Bacterial endotoxins ≤0.6EU/mg <0.6EU/mg

 

Company Introduction:

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