Procaine / Novocaine CAS 59-46-1
Procaine Base Novocain powder Local Anesthetic Drugs 59-46-1 , topical dental anesthetic
1. Quick Detail:
English name: procaine
English Synonyms: 2-diethylaminoethyl 4-aminobenzoate; novocaine
EINECS Number: 200-426-9
Density: 1.077g / cm3
Boiling point: 373.6 ° C at 760 mmHg
Flash Point: 179.8 ° C
Vapor Pressure: 8.84E-06mmHg at 25 ° C
Appearance:White crystalline powder
Procaine is a local anesthetic drug of the amino ester group. It is used primarily to reduce the pain of intramuscular injection of penicillin, and it is also used in dentistry. Owing to the ubiquity of the trade name Novocain, in some regions procaine is referred to generically as novocaine. It acts mainly as a sodium channel blocker. Today it is used therapeutically in some countries due to its sympatholytic, anti-inflammatory, perfusion enhancing, and mood enhancing effects.
- Procaine application before removal of a decayed tooth
- The primary use for procaine is as an anaesthetic.
Procaine is used less frequently today since more effective (and hypoallergenic) alternatives such as lidocaine (Xylocaine) exist. Like other local anesthetics (such as mepivacaine, and prilocaine), procaine is a vasodilator, and is thus often coadministered with epinephrine for the purpose of vasoconstriction. Vasoconstriction helps to reduce bleeding, increases the duration and quality of anesthesia, prevents the drug from reaching systemic circulation in large amounts, and overall reduces the amount of anesthetic required. Unlike cocaine, a vasoconstrictor, procaine does not have the euphoric and addictive qualities that put it at risk for abuse.
Procaine, an ester anesthetic, is metabolized in the plasma by the enzyme pseudocholinesterase through hydrolysis into para-amino benzoic acid (PABA), which is then excreted by the kidneys into the urine.
Procaine is the primary ingredient in the controversial preparation Gerovital H3 by Ana Aslan (Romania), which is claimed by its advocates to remedy many effects of aging. The mainstream medical view is that these claims were seriously studied and discredited in the 1960s.
A 1% procaine injection has been recommended for the treatment of extravasation complications associated with venipuncture (along with moist heat, ASA, steroids, antibiotics). It has likewise been recommended for treatment of inadvertent intra-arterial injections (10 ml of 1% procaine), as it helps relieve pain and vascular spasm.
Procaine is an occasional additive in illicit street drugs, such as cocaine. MDMA manufacturers also use procaine as an additive at ratios ranging from 1:1 up to 10% MDMA with 90% procaine, which can be life-threatening.
|Test Items||Specification||Test Results|
|Appearance||White crystals or a white crystalline powder||Conform|
|Identification||ABE. It appears positive reaction|
|Appearance of solution||Clear and colourless||Conform|
|Loss on drying||≤0.5%||0.07%|
|Assay ( on dry basis )||99.0-101.0%||99.87%|
|Conclusion||Conform to BP2005|
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