Raloxifene Hydrochloride CAS 82640-04-8
01 Overview
Raloxifene is a selective estrogen receptor modulator (SERM); acts as an anti-estrogen in both breast and uterine tissue while being estrogenic in bone. May have efficacy against estrogen-sensitive cancers.
raloxifene-hydrochloride-1
Raloxifene Hydrochloride02 Details
Anti-Estrogens Female Hormone Steroids Raloxifene Hydrochloride / Raloxifene HCl CAS 82640-04-8
Quick Detail:
Raloxifene Hydrochloride
CAS No: 82640-04-8
Purity: 99%
Molecular formula: C28H28ClNO4S
Molecular Weight: 510.04
Appearance: Light yellow solid
Nominal Mass: 509 Da
Average Mass: 510.0442 Da
Monoisotopic Mass: 509.142756 Da
Flash Point: 394.2 °C
Boiling Point: 728.2 °C at 760 mmHg
Vapour Pressure: 6.46E-22 mmHg at 25 °C
Solubility: DMSO: 28 mg/mL, soluble
Packing: as your requires
Description:
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Raloxifene is a selective estrogen receptor modulator (SERM); acts as an anti-estrogen in both breast and uterine tissue while being estrogenic in bone. May have efficacy against estrogen-sensitive cancers.
Applications:
Reduction in the incidence of invasive breast cancer in postmenopausal women with osteoporosis.
in 2006, the National Cancer Institute announced that raloxifene was as effective as tamoxifen in reducing the incidence of breast cancer in postmenopausal women at increased risk,
EVISTA (raloxifene hydrochloride) is an estrogen agonist/antagonist, commonly referred to as a selective estrogen receptor modulator (SERM) that belongs to the benzothiophene class of compounds The chemical designation , [6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl]-[4-[2-(1-piperidinyl)ethoxy]phenyl]-, hydrochloride.
Raloxifene hydrochloride (HCl) has the empirical formula C28H27NO4S.HCl, which corresponds to a molecular weight of 510.05. Raloxifene HCl is an off-white to pale-yellow solid that is very slightly soluble in water.
Coa:
| Test items | Specification | Test results | |
| Appearance | Yellowish powder | Comply | |
| Identification | Ir | Comply | |
| It meets the requirements of the test for choride | Comply | ||
| Solubility | Soluble in 10% sodium hydroxide solution,
slightly soluble in methanol,insoluble in water |
Comply | |
| Assay | 98.5%~101.5% | 99.15% | |
| Related substances | Rrt=0.74 impurity | ≤0.20% | Comply |
| Other single impurity | ≤0.10% | 0.07% | |
| Total impurities | ≤0.5% | 0.26% | |
| Loss on drying | ≤0.5% | 0.10% | |
| Residue on ignition | ≤0.1% | Comply | |
| Heavy metals | ≤10ppm | Comply | |
| Storage | Preserve in well-closed containers and protected from light.Store at room temperature. | ||
| Conclusion | Complies with usp32 standard | ||
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