Tetracaine Hydrochloride CAS 136-47-0

01 Overview

Tetracaine (INN, also known as amethocaine; trade name Pontocaine. Ametop and Dicaine) is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia.

02 Details

Purity 99% Local Anesthetic Agents , Pain Easing Tetracaine Hydrochloride /Tetracaine HCL CAS 136-47-0

 

 

Basic View:

 

  • Tetracaine HCl
  • Alias : Tetracaine hydrochloride ,2-Dimethylaminoethyl 4-n-butylaminobenzoate   hydrochloride;
  • 4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester hydrochloride
  • CAS NO : 136-47-0
  • EINECS : 205-248-5
  • MF : C15H25ClN2O2
  • MW : 300.82
  • Melting point : 149°C
  • Assay : 99%
  • Grade : Pharmaceutical Grade
  • Storage : Closed, confined and shading preservation
  • Manufacturer : Yi jing
  • Usage : Local anesthetic; Mainly used in mucosa anesthetic. The function is stronger than
    Procaine and Lidocaine.

 

 

Brief Introduction:

 

Tetracaine HCl is synthesized from 4-butylaminobenzoic acid. The ethyl ester is formed through an acid-catalyzed esterification reaction. Base-catalyzed transesterification is achieved by boiling the ethyl ester of 4-butylaminobenzoic acid with excess 2-dimethylaminoethanol in the presence of a small amount of sodium ethoxide.

 

 

Usages:

 

1. Tetracaine (INN, also known as amethocaine; trade name Pontocaine. Ametop and Dicaine) is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia.

 

2. In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores.

Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.

 

 

COA:

 

Test Items Specification Test Results
Appearance Fine, white, crystalline, odorless powder confirm
Identification ABC in Pass confirm
Solubility Very soluble in water, soluble in Alcohol;
insoluble in Ether and Benzene
confirm
USP Reference standards USP Tetracaine Hydrochloride RS.
USP Endotoxin RS.
confirm
Melting point 145~150 degree 146.0~147.5

degree

Chromatographic purity In Pass confirm
Related substance Not more than the reference solution 0.05% confirm
Heavy metals ≤10ppm confirm
PH 4.5-6.5 5.8
Residue on ignition ≤0.10% 0.05%
Loss on Drying ≤ 0.5% 0.19%
Assay 98.0 -101.0% 100.1%
Conclusion Confirms USP 32

 

 

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