Tetracaine Hydrochloride CAS 136-47-0
01 Overview
Tetracaine (INN, also known as amethocaine; trade name Pontocaine. Ametop and Dicaine) is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia.
tetracaine-hcl
Tetracaine Hydrochloride02 Details
Purity 99% Local Anesthetic Agents , Pain Easing Tetracaine Hydrochloride /Tetracaine HCL CAS 136-47-0
Basic View:
- Tetracaine HCl
- Alias : Tetracaine hydrochloride ,2-Dimethylaminoethyl 4-n-butylaminobenzoate hydrochloride;
- 4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester hydrochloride
- CAS NO : 136-47-0
- EINECS : 205-248-5
- MF : C15H25ClN2O2
- MW : 300.82
- Melting point : 149°C
- Assay : 99%
- Grade : Pharmaceutical Grade
- Storage : Closed, confined and shading preservation
- Manufacturer : Yi jing
- Usage : Local anesthetic; Mainly used in mucosa anesthetic. The function is stronger than
Procaine and Lidocaine.
Brief Introduction:
Tetracaine HCl is synthesized from 4-butylaminobenzoic acid. The ethyl ester is formed through an acid-catalyzed esterification reaction. Base-catalyzed transesterification is achieved by boiling the ethyl ester of 4-butylaminobenzoic acid with excess 2-dimethylaminoethanol in the presence of a small amount of sodium ethoxide.
Usages:
1. Tetracaine (INN, also known as amethocaine; trade name Pontocaine. Ametop and Dicaine) is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia.
2. In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores.
Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.
COA:
| Test Items | Specification | Test Results |
| Appearance | Fine, white, crystalline, odorless powder | confirm |
| Identification | ABC in Pass | confirm |
| Solubility | Very soluble in water, soluble in Alcohol; insoluble in Ether and Benzene |
confirm |
| USP Reference standards | USP Tetracaine Hydrochloride RS. USP Endotoxin RS. |
confirm |
| Melting point | 145~150 degree | 146.0~147.5
degree |
| Chromatographic purity | In Pass | confirm |
| Related substance | Not more than the reference solution 0.05% | confirm |
| Heavy metals | ≤10ppm | confirm |
| PH | 4.5-6.5 | 5.8 |
| Residue on ignition | ≤0.10% | 0.05% |
| Loss on Drying | ≤ 0.5% | 0.19% |
| Assay | 98.0 -101.0% | 100.1% |
| Conclusion | Confirms USP 32 | |
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