Trimegestone CAS 74513-62-5
Trimegestone (brand name Ondeva), also known as 21-hydroxypromegestone, as well as 17β-((S)-2-hydroxypropanoyl)-17α-methylestra-4,9-dien-3-one, is a steroidal progestin of the 19-norprogesterone group related to promegestone which was introduced in France in 2001 and is used as a hormonal contraceptive and in hormonal replacement therapy for postmenopausal symptoms.
New Generation of Progestogen Powder Trimegestone (CAS 74513-62-5)
Product Name: Trimegestone
Alias: Trimegestone [INN]; RU 27987; Estra-4,9-dien-3-one, 17- (2-hydroxy-1-oxopropyl) -17-methyl-, (17beta (S)) -; Totelle Sekvens, Ondeva; UNII-4658K0H08W; 17beta- (S) -Lactoyl-17-methylestra-4,9-dien-3-one; (17beta) -17 – [(2S) -2-hydroxypropanoyl] -17-methylestra-4, 9-dien-3-one
Molecular formula: C22H30O3
InChI: InChI = 1 / C22H30O3 / c1-13 (23) 20 (25) 22 (3) 11-9-19-18-6-4-14-12-15 (24) 5-7-16 (14) 17 (18) 8-10-21 (19,22) 2 / h12-13,18-19,23H, 4-11H2,1-3H3 / t13-, 18 +, 19-, 21-, 22 + / m0 / s1
Molecular Structure: 74513-62-5 trimegestone
Density: 1.16g / cm3
Boiling point: 522.6 ° C at 760 mmHg
Flash Point: 284 ° C
Vapor Pressure: 4.16E-13mmHg at 25 ° C
Appearance:white or almost white powder.
Trimegestone (brand name Ondeva), also known as 21-hydroxypromegestone, as well as 17β-((S)-2-hydroxypropanoyl)-17α-methylestra-4,9-dien-3-one, is a steroidal progestin of the 19-norprogesterone group related to promegestone which was introduced in France in 2001 and is used as a hormonal contraceptive and in hormonal replacement therapy for postmenopausal symptoms. It is not available in the United States.
Trimegestone has very high affinity for the progesterone receptor, only weak affinity for the mineralocorticoid receptor, and little or no affinity for other steroid hormone receptors.In accordance, it is described as a very potent and pure progestogen,in fact the most potent progestin of the 19-norprogesterone group (clinically effective in endometriosis at only 0.1 mg/day), and possesses weak antimineralocorticoid activity and noandrogenic, antiandrogenic, estrogenic, or glucocorticoid activity.Due to its unique structure, unlike progesterone and some other progestins, trimegestone does not metabolize into neuroactive steroids, and hence does not influence GABAA receptor signaling.
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